New Oral Angiogenesis Inhibitor Offers Potential Nontoxic Therapy For A Wide Range Of Cancers Jul 1, 2008
Tested in mice, Lodamin had a significantly increased half-life, selectively accumulated in tumor tissue, blocked angiogenesis, and significantly inhibited primary tumor growth in mouse models of melanoma and lung cancer, with no apparent side effects when used at effective doses. Subsequent tests suggest that Lodamin retains TNP-470 s unusually broad spectrum of activity. (Science Daily)
Radioactive house 'unfit to live in' Jun 25, 2008
has a very long half life (4,5 billion years). So, the radioactivity in the said abodes , would not have disappeared in a meagre (1 century) time period. (ABC Online)
Potential Protein Biomarkers For Growth Hormone Identified Jun 23, 2008
Growth hormone is hard to detect because it has a serum half life of only 15 minutes. RhGH, an approved drug for individuals with growth hormone deficiency, also is identical to human growth hormone. (Science Daily)
San Francisco's DJ WiiJ Mixes And Mashes Music With A Unique Tool: Nintendo's Wii Jun 20, 2008
There are videos and step-by-step walkthroughs showing users how to navigate around Google Earth, play "Half-Life 2" and even manipulate an interactive whiteboard. DJ WiiJ first premiered online in the same fashion, but he eventually took his skills to the stage, debuting at San Francisco's Bootie bar in May 2007. (VHI.com -- Music News)
Anybody want some plutonium? Jun 14, 2008
THE half-life of official opposition to nuclear power in Britain has been very short. In its first energy white paper in 2003, the government was disdainful, devoting most of its time to wind and solar power. (The Economist)
The Lighter Side Jun 4, 2008
" Investigations revealed the horrific truth: radioactive material was seeping into the koeksisters. "It was a nightmare", says Oom Kallie. "People were poeping out things with a half-life of 5,000 years. " However, he says he and the folk of Orania are looking forward. "That is our motto. (iAfrica.com)
Political gaffes have been around for generations Jun 3, 2008
"In this current environment, [a story's] half life is reduced dramatically," Fielder said. "Because the next thing that comes along, even if it's not anywhere near as significant, takes its place.". (Boston Globe)
Don't make vacation thieves' holiday Jun 3, 2008
Your credit s half life will last 40 thousand freakin years. Special Isotopes available in New York, New Hampshire, and Vermont. (Atlanta Journal-Constitution)
Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO Jun 2, 2008
Pharmacokinetic analyses indicate that the half-life of XL184 was approximately 100 hours (range 59-136 hours), with exposure at the MTD exceeding that required for efficacy in preclinical models. Pharmacodynamic analyses demonstrated statistically significant changes at the MTD in plasma markers including VEGF-A, PlGF, and soluble VEGFR2, similar to the effects of other anti-angiogenic agents, and consistent with the anti-VEGFR activity of XL184. (PR Newswire)
Trudging the long road to love can be extremely painful in six-inchheels May 31, 2008
The settlers are the anti-heroines - those not courageous enough to gamble on the ultimate prize - true love, those who find that settling has resulted in a desperate half-life, a la Madame Bovary. In a searcher's world there are no arguments about the late fine at the DVD shop or who ate all the cheese - just bliss, bliss, bliss. (Sydney Morning Herald -- Opinion)
Glad You Asked: What is the shelf life of a Twinkie? May 27, 2008
Some hint the scrumptious yellow snack has a half-life and could survive nuclear fallout. There is no good reason to keep a Twinkie any longer than about five minutes. (Racine Journal Times, WI)
Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis May 21, 2008
Preliminary Phase 1 data have demonstrated that RDEA119 has a long half-life and favorable pharmacokinetic properties, allowing for once daily oral dosing ... In addition, RDEA436 has demonstrated a long half-life in a human micro-dose pharmacokinetic study, with the potential for once daily dosing in humans. (PR Newswire)
Old antibiotic may find new life as a stroke treatment May 20, 2008
We are going to be drawing samples from patients to make sure we achieve the concentrations that we want in the blood, plus we want to define the half-life in stroke patients to see if its different than in the younger patients who take it for other reasons, says Dr. Fagan ... If the half-life is longer, we can give it less frequently. (EurekAlert!)
Pediatrician testifies at infant-death trial May 17, 2008
grasping at straws wrote on May 16, 2008 9:31 AM:" The half life of Heparin is about 90 minutes, meaning when you give a dose, half of it's therapeutic effect is gone in 90 minutes. In another 90 minutes, half of that will be gone and another 90 minutes, half of that . . . . ". Lija wrote on May 16, 2008 9:48 AM:" Guilty guilty guilty. Hope they lock him up and throw away the key. Of course, in this day and age if he's convicted he'll be out in a year. What a sick twisted monster. ". (Longview Daily News, WA)
Valve's Hardware Survey Results May 16, 2008
May 15, 2008 - Valve, the developer of Half-Life 2 and Team Fortress 2, recently conducted a Steam hardware survey, and the results are in;you have two weeks to live. Ok, so maybe it's slightly shy of being that dramatic. (IGN PC Games)
Genesis of Planets: Meteorites--Emissaries from the Past May 13, 2008
Researchers believe that this heating was brought about by the radioactive isotope aluminum 26, which has a half-life of 700,000 years. A supernova explosion or nearby star probably seeded the protosolar cloud with this isotope, in which case the first generation of planetesimals in our solar system contained plenty of it. (Scientific American)
Infinity Highlights Promising Preclinical Hedgehog Data and Announces First Quarter Financial Results May 5, 2008
As presented at AACR, preclinical studies evaluating IPI-926 in a novel mouse model of medulloblastoma demonstrated that the compound has excellent pharmaceutical properties in vivo, including oral bioavailability, potent inhibition of the Hedgehog pathway, long plasma and tumor half-life, and dose-dependent inhibition of tumor growth. Once-daily dose administration of IPI-926 in this model resulted in 100 percent survival while on treatment, and median overall survival of 48 days, or a... (Primezone Releases)
Targanta Announces Highlights of Oritavancin Data to Be Presented at the 18th ECCMID Apr 19, 2008
Due to oritavancin s long half life and demonstrated concentration-dependent bactericidal activity, the approach presented here proved useful in selecting the dosing regimen for the study. Further, the speaker postulates that front-loaded regimens are likely to result in improved response rates for patients with cSSSI relative to other antibiotic regimens previously studied. (BusinessWire)
Greener Grass: You can have a beautiful lawn that is environmentally friendly, too Apr 19, 2008
Another popular herbicide, glyphosate, has a half-life of 47 days, and in 1996 total application in the country was between 2,200 and 3,300 tons. Their study also noted that lawn chemicals are applied at about three times the rate of agricultural chemicals, and that while agricultural chemical use decreased by 12,189 tons from 1992 to 1997, lawn chemical use increased by 7,747 tons. (Racine Journal Times, WI)
Heart Support Apr 19, 2008
"When the half-life of these new technologies exceeds that of heart transplants, they'll take over. I don't think we're far away from that.". More On This Topic Companies. (Forbes -- Business)
The sunshine vitamin Apr 18, 2008
The difficulty with vitamin D is it has a half-life, in other words it remains in the body and an overdose is possible. If you consume excess amounts of vitamin D it can be toxic, possibly leading to kidney stones or kidney damage, weak muscles and bones, excessive bleeding, and other problems. (Suite101.com)
Not in My Back Yucca Apr 15, 2008
Nevada's anti-Yucca dossier neatly summarizes this optimistic attitude: "It is almost inconceivable that progress in waste treatment and disposal methods will cease over the next century." There are several promising techniques in the pipeline, starting with , in which proton beams are used to reduce a substance's half-life. ATW is a favorite of Sen. (Slate)
The good and bad side of anti-cancer compounds Apr 11, 2008
I think the short half-life in people is actually going to be a benefit for these compounds, because they are transient therapies, he noted. Hieberts lab is following these mice to determine the long-term effects of HDAC inhibition. (EurekAlert!)
Pilot in bay spill had past incidents Apr 10, 2008
The pills have a half-life of 11 or 12 hours and "that's not something you'd want to have onboard when you're trying to do important duties," the doctor said. Bourgeois said the medications could have interacted with each other to exacerbate side-effects. (MSNBC -- Environment)
New Data On Infinity's Lead Anti-Cancer Candidates to be Presented At AACR Apr 7, 2008
When systemically administered in multiple preclinical animal models, IPI-926 has shown potent and selective inhibition of the Hedgehog pathway, anti-tumor activity, and attractive pharmacologic properties including oral bioavailability and extended half-life. About Infinity Pharmaceuticals, Inc.. (Primezone Releases)
Momenta Pharmaceuticals Announces Presentation of M118 Phase 1 Results At the American Society for Clinical Pharmacology and Therapeutics Annual Meeting Apr 4, 2008
Mean elimination half-life was approximately 1 hour (range 0. 83-1. (Primezone Releases)
Platelet-Activating Factor, PAF Acetylhydrolase, and Anaphylaxis Apr 3, 2008
This is an important consideration when a patient is in unstable condition2 and is important with PAF's short half-life. On the basis of the authors' suggestion that blocking PAF may alter clinical outcomes, it is important to correlate PAF levels temporally. (New England Journal of Medicine)
ISAR-REACT 3 Pits Bivalirudin vs. Unfractionated Heparin in PCI Mar 30, 2008
"We hypothesized that in patients who were optimally pre-treated with clopidogrel, bivalirudin would continue to prove superior to unfractionated heparin, at least in terms of safety -- by reducing bleeding side effects." Bivalirudin has several potential advantages over unfractionated heparin: It does not rely on antithrombin to achieve its effects, it has a more predictable dose-response pattern (and, therefore, does not require routine blood test monitoring) and it has a short plasma... (PR Newswire)
Canadians still trashing TVs, batteries and meds Mar 28, 2008
And the plastics they are packed in take forever to decompose or degrade to a half-life. They should be banned. (CTV.ca)
DPH comes to town Mar 22, 2008
Mr. Toal pointed out that uranium has "a low radiation rate," with "a half life of 4.5 billion years." In response to the question of whether school districts could establish standards regarding uranium in school drinking water, he said, "I don't know of any schools that have done this," adding, however, that school districts could "adopt policy" to address it. Mr. Toal agreed that the distribution of bottled water was the right action to take at HHES because of the difficulty of mitigation in... (Brookfield Journal, CT)
Pam Reinig: Easter mania Mar 22, 2008
Like the tinsel people foolishly drape on Christmas trees, Easter grass has the half-life of uranium. It simply cannot be destroyed. (Ames Daily Tribune, IA)
Dogged determination Mar 10, 2008
She just wrapped up a casting stint with the Tony-award winning Broadway musical "The 25th Annual Putnam County Spelling Bee." She also directed Anna Chlumsky ("My Girl") in "Half Life," which was one of the most buzzed-about shows at the 2005 New York International Fringe Festival ... "Half Life," by Robert Moulthrop, is a living-room drama about a teacher who molests a student. (Anchorage Daily News)
Dodges Challenge: Win back America Mar 5, 2008
Thats the problem historically with coupes their half-life is two years because somebody else comes out with something newer. . (MSNBC -- Terrorism)
Arsenic-Labeled Antibody Shows Tumor Imaging Potential Mar 5, 2008
Personalize Your Medical News. PUTTING BREAKING MEDICAL NEWS INTO PRACTICE Wednesday, March 05, 2008. (MedPage Today)
Underground tools foil generic virus detection Mar 4, 2008
Back in the day malware authors wanted to make a name for themselves by causing trouble; these days they're more interested in making sure of extending the half-life of money-making malware by making sure it attracts the minimum of attention and, as far as possible, creeps in under the radar of anti-virus tools. Non-disclosure testing of malware toolkits prior to this release aids this process, as well as creating income for unscrupulous coders happy to work for VXers. (Register)
Rumour: Apple Wants Sony Blu-ray Drives for MacBook Pros Mar 4, 2008
But, Apple's official support for Blu-ray has been completely non-existent despite its exceedingly long rumour half-life. On the other hand, Blu-ray's victory logically means we'll see them populating more computers in (sorta) short order, now that the risk of shipping machines with US$300 drink holders is gone. (Gizmodo Australia)
Obama Reassures On Israel Feb 29, 2008
"But with the Internet, as all Jews should know, these things have a half-life. They just keep going.". Rep. (CBS News)
A short half-life for a new series Feb 29, 2008
Local Search Site Search. THIS STORY HAS BEEN FORMATTED FOR EASY PRINTING. (Boston Globe)
Can You Support McCain? Feb 29, 2008
All three supported Romney in the caucuses, believing he was the most conservative" of the bunch. Electability in November was only a factor for one.]HE: When it FIRST became clear that McCain would be the nominee, for what reason(s) did you believe you couldn't vote for him?JM: McCain/Feingold, not supporting Bush tax cuts, and he is too old.KM: Some of his compromises seemed more like capitulations of principle, not being a maverick. The gang of 14 comes to mind.MH: My biggest fear about... (Human Events Online)
Health Dept. says 3M chemical levels safe in east Twin Cities Feb 29, 2008
"PFBA has a significantly shorter half-life in a human being's body. And so that shorter duration within the human body is the primary reason for lessening our concern," Stine told Minnesota Public Radio. The revised exposure number means all the east metro municipal wells that had previously tested positive for PFBA are now well within the safety limit. (Brainerd Daily Dispatch)
Calls grow to halt Canada's isotope dominance Feb 26, 2008
Nordion supplies 65 per cent of the U.S. market - and 50 per cent of the global market - for the molybdenum isotope, which has an extremely brief half-life and is used in some 35,000 medical images per day in the U.S. alone. With its black eye over Chalk River and a dry spell in international reactor sales, the future of AECL remains uncertain. (Globe and Mail -- National)
Steam to Offer Video and Music? : Valve's Doug Lombardi reveals ambitions for do... Feb 26, 2008
Elsewhere in the interview the company stalwart again reiterated that further Portal content is in the works and spoke about Half Life 2: Episode 3, which is looming on the distant horizon. "We're not going to rush Episode Three," said Lombardi, "We'll be working on Episode Three sometime soon, but there's no specific roadmap yet for the game's release.". (IGN PC Games)
Born after 1950? Your eyes reveal your age Feb 24, 2008
Your eyes reveal your age / Radioactive material in lens can be dated, Danish study finds (San Francisco Chronicle)
Age Of Fish Can Be Determined Through Cold War Era Radiocarbon Traces Feb 22, 2008
C-14 has a half-life of 5,730 years. After the increase from the test bombing, C-14 has been decaying slowly in the environment, giving scientists a benchmark level for each year. (Science Daily)
ConjuChem Initiates Phase II Study of PC-DAC(TM):Exendin-4 Feb 20, 2008
The clinical utility of Exendin-4 is somewhat limited by its relatively short half-life in plasma ... Data from Phase I/II clinical studies have demonstrated that the preformed albumin-peptide conjugate has a much longer half-life than the peptide alone. (Canada Newswire)
Growing push for egg-farm closure Feb 18, 2008
Welcome to Mercury - The Voice of Tasmania. February 18, 2008 12:00am. (NEWS.com.au)
Zydus Cadila introduces Nudoxa cancer drug Feb 18, 2008
A further advancement in this line of treatment was the Pegylated-liposomal doxorubicin, a unique form of liposomal doxorubicin in which the liposomes are coated with polyethylene glycol, leading to a much longer half-life in the blood. However Pegylated-liposomal doxorubicin are likely to cause Hand-Foot Syndrome, characterized by skin eruptions on the palms of the hand or soles of the feet, leading to interruption in therapy. (Health Newstrack)
BlackBerry Outage Frustrates Users Again Feb 12, 2008
Welcome to The Sydney Morning Herald. February 12, 2008 - 8:34PM. (Sydney Morning Herald -- Technology)
First Vista update: the missing link Feb 12, 2008
Hey, I'd play this game, and I love the God of War series and the Half-Life series. . (Sydney Morning Herald)
Helium-8 Study Gives Insight Into Nuclear Theory, Neutron Stars Feb 7, 2008
Helium-8 has a half-life of only a tenth of a second, meaning that samples of the atom have to be measured "on-line," or immediately after they are produced, which is not easy in the first place. Scientists require high-power accelerators to create even a tiny quantity of these atoms. (Science Daily)
Saved by the dog Feb 6, 2008
"It takes five hours of breathing regular air for that [level] to be cut in half. ... On the other hand, if we put you in the chamber, we reduce the half-life to 20 minutes.". The Grazianis are slowly recovering. (Pittsburgh Post-Gazette, PA)
Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells Feb 6, 2008
Previous studies have shown that senicapoc prevents the loss of potassium from the RBCs, is well tolerated, and has favorable pharmacokinetics with a long half-life, permitting once-daily dosing. In a 12-week, multicenter, phase II, randomized, double-blind, dose-finding study, senicapoc was evaluated for its effect on hemoglobin level and markers of RBC destruction (hemolysis) in SCD patients. (EurekAlert!)
SXSW announces line-up Feb 5, 2008
Jennifer Phang's "Half-Life" will play in with Emerging Visions. Clark Gregg's "Choke" and Margaret Browns Mardi Gras docu "The Order of Myths" screen in Spotlight. (Variety)
Sanofi-Aventis could face antitrust charges if company loses Lovenox patent case Feb 5, 2008
The case involves whether Sanofi-Aventis knowingly misled the Patent and Trademark Office when comparing Lovenoxs half-life to the prior art. Amphastar and Teva are alleging that Sanofi-Aventis compared Lovenox to another drug at a different dose, when their drug would have had the same half life if it had been compared at the same dosage, according to Amphastars attorney Jan Weir. (FT.com -- Markets)
Unravelling carbon's chemical secrets Feb 2, 2008
While oxygen-14 has a half-life of around 70 seconds, the half-life of carbon-14 is 5,730 years. With a lifetime measured in millennia rather than minutes, researchers can use the decay of carbon-14 to date ancient artefacts. (Nature News Service)
Mercury in Childhood Vaccines Excreted Quickly Feb 1, 2008
Pichichero's group found that for all three age groups, the half-life of ethyl mercury in the blood -- the time it takes for the body to get rid of half the mercury, and then another half, and so on -- was 3 ... That's significantly less than the half-life of methyl mercury, the kind found in fish, at 44 days ... "Until recently, that longer half-life was assumed to be the rule for both types of mercury. Now it's obvious that ethyl mercury's short half-life prevents toxic build-up from... (MEDLINEplus)
Leaded apartment in Roslindale leads to poisoning of a child Jan 31, 2008
The body holds on to lead because it thinks it s calcium or iron and wants to store it It has a half-life of 4. 5 years. (West Roxbury Transcript, MA)
Infant study casts doubt on vaccine-autism link Jan 31, 2008
Blood tests showed the half-life of ethyl mercury -- the time it takes for the body to dispose of half of it -- was 3 ... The more dangerous methyl mercury, known to damage nerves, has a half-life of 44 days ... "Until recently, that longer half-life was assumed to be the rule for both types of mercury," Pichichero said. (Reuters)
Sundance Film Festival gets greener Jan 23, 2008
"Half-Life" is a fictional film telling of a future time period of natural disasters and poor air quality. In the festival's New Frontier section for video art and performance pieces, Marina Zurkow is showing an animated installation dealing with ocean pollution and melting polar ice caps, and "DJ Spooky" Paul Miller is performing his piece that portrays the transformation of the Antarctica. (MSNBC -- Environment)
Nuclear waste concerns resurface Jan 21, 2008
Higher-level leftovers includes plutonium-239, with a half-life of 24,000 years. Direct exposure to such highly radioactive material, even for a short period, can be fatal. (MSNBC -- Environment)
Lewis: The ACTION 5! Jan 17, 2008
" This five-disc collection (which comes packed with cool toys and art pieces in a silver suitcase) starts out with a brand new "Final Cut" version of the film which is fantastic but the real treat is the intensive four-hour "making of" documentary which covers everything from concept to screen. This set is a must own for film buffs! Hint: Don't be scared off by the whopper of a list price ( $99.98), you can find this set for far cheaper at leading online retailers. 2 'Control' Renowned... (Athens Banner-Herald)
From the ashes| Jan 10, 2008
That's the nature of highly radioactive material, some of it with a half-life of just hours. In fact, the deterioration starts the moment the raw material is produced. (iAfrica.com)
Radioactive 'understudy' may aid medical imaging, drug development Jan 10, 2008
This germanium isotope is much longer livedits half-life is 270. 95 daysbut its radiation decay characteristics are otherwise similar to fluorine-18. (EurekAlert!)
OPINION -- Speaking of humor ... let me know which comic strip tickles Jan 9, 2008
Governmentium has a normal half-life of four years. It does not decay, but instead undergoes a reorganization in which a portion of the assistant neutrons and deputy neutrons exchange places. (Canton Daily Ledger, IL)
Making McCain's Momentum Count for More Jan 9, 2008
But it's worth remembering that the arguments of consultants have a half-life shorter than a gnat in this race. McCain's campaign in New Hampshire is itself evidence of the unpredictability of this election. (Time.com)
